Throughout history, relationships between blood relatives have been viewed differently across cultures. While some societies encouraged such relationships to maintain family unity, as seen in ancient Egypt, others, including many U.S. states, prohibit them due to the potential health risks for offspring.
Increased Risk of Genetic Disorders in Consanguineous Relationships
When both parents are blood relatives, they share a greater proportion of their genes, increasing the likelihood that both may carry the same recessive mutations. Autosomal recessive disorders occur when both copies of a gene are mutated, leading to a 25% chance that the child will inherit the disorder if both parents carry the same mutation. While the risk decreases with more distant relatives, it remains significantly higher than in unrelated couples. Studies estimate that the risk of passing on a genetic disorder in consanguineous relationships is 1.7 to 2.8 times higher than in non-related couples.
Ensuring Healthy Offspring with Genetic Testing
To reduce the risks, modern genetic testing, such as the Genetic Compatibility Test (GCT), is highly recommended for blood-related couples. This test screens for over 600-3,000 recessive genetic conditions. If both partners are carriers of the same genetic mutation, they can opt for Preimplantation Genetic Diagnosis (PGD) during IVF. This technique allows the selection of embryos free from the inherited disorder, ensuring the birth of healthy children.
At Nicosia Fertility, we offer advanced genetic testing and PGD to help couples make informed decisions and minimize risks, even in consanguineous relationships.
For more information on genetic testing and solutions for couples who are blood relatives, contact us at Nicosia Fertility.
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